Y-family DNA polymerases in mammalian cells |
| |
Authors: | Caixia Guo J Nicole Kosarek-Stancel Tie-Shan Tang Errol C Friedberg |
| |
Institution: | (1) Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9072, USA;(2) Beijing Institute of Genomics, Chinese Academy of Science, 100029 Beijing, China;(3) State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Science, 100101 Beijing, China |
| |
Abstract: | Eukaryotic genomes are replicated with high fidelity to assure the faithful transmission of genetic information from one generation
to the next. The accuracy of replication relies heavily on the ability of replicative DNA polymerases to efficiently select
correct nucleotides for the polymerization reaction and, using their intrinsic exonuclease activities, to excise mistakenly
incorporated nucleotides. Cells also possess a variety of specialized DNA polymerases that, by a process called translesion
DNA synthesis (TLS), help overcome replication blocks when unrepaired DNA lesions stall the replication machinery. This review
considers the properties of the Y-family (a subset of specialized DNA polymerases) and their roles in modulating spontaneous
and genotoxic-induced mutations in mammals. We also review recent insights into the molecular mechanisms that regulate PCNA
monoubiquitination and DNA polymerase switching during TLS and discuss the potential of using Y-family DNA polymerases as
novel targets for cancer prevention and therapy. |
| |
Keywords: | Y-family polymerase PCNA Replication foci Translesion DNA synthesis Mutagenesis Polymerase switching Somatic hypermutation |
本文献已被 SpringerLink 等数据库收录! |
|