Reserpin und Glykogengehalt der Organe |
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Authors: | H Balzer P Holtz D Palm |
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Institution: | (1) Pharmakologisches Institut der Universität Frankfurt a. M., Deutschland |
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Abstract: | Summary In fasted white mice, 1–18 h after the injection of 5 mg/kg Reserpine the glycogen content of brain, heart, skeletal muscle and liver is significantly increased (about 100%, in liver nearly 300%). It is suggested that this is due to an enhanced synthesis of glycogen from non-carbohydrate material.Concerning the underlying mechanism, it is pointed out that after reserpine there occurs a release of catecholamines from the adrenal medulla and-by stimulation of the anterior pituitary-an enhanced production of corticoids.Simultaneously with the increase of the brain glycogen, the level of lactic acid is decreased, whereas the ATP-, ADP- and AMP-content of the brain remains practically unaffected.
Ausgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft. |
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