Myocardial dystrophin immunolocalization at sarcolemma and transverse tubules |
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Authors: | R Yarom G E Morris R Froede J Schaper |
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Institution: | (1) Hadassah Medical School, Jerusalem, (Israel);(2) Research Division N E Wales Institute, Deeside, Clwyd, (UK);(3) Department of Experimental Cardiology, Max-Planck Institute, Bad-Nauheim, (Germany) |
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Abstract: | Using monoclonal antibodies against two different regions of the helical rod part of dystrophin1, we have localized dystrophin on both plasma membrane and transverse tubules in cardiac muscle of man and several animal species. The staining persisted after experimental ischaemia, and was observed in long-standing heart disease. No immunostaining was seen at the intercalated discs. In skeletal muscle the same two antibodies stained only the plasma membrane. |
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Keywords: | Dystrophin transverse tubules myocardium ischaemia muscular dystrophy |
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