| 小檗碱和葛根素对卵巢颗粒细胞胰岛素抵抗的调控 |
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| 引用本文： | 姚晶萍,邱学敏,高磊,吴效科,侯丽辉,倪延群.小檗碱和葛根素对卵巢颗粒细胞胰岛素抵抗的调控[J].科技导报(北京),2008,26(9):37-41. |
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| 作者姓名： | 姚晶萍 邱学敏 高磊 吴效科 侯丽辉 倪延群 |
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| 作者单位： | 1. 哈尔滨医科大学附属肿瘤医院妇科，哈尔滨 1500402. 黑龙江中医药大学附属第一医院妇产和核医学科，哈尔滨 1500403. 哈尔滨市社会保险局医院，哈尔滨 150030 |
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| 基金项目： | 中国-芬兰科学技术合作基金
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国家自然科学基金
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黑龙江省自然科学基金 |
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| 摘 要： | 建立了体外的卵巢胰岛素抵抗模型。从卵巢内分子水平探讨胰岛素信号传导和促性腺激素信号传导的相互关系，揭示多囊卵巢综合征患者糖代谢异常和生殖功能障碍的关系；通过药物筛选得出两味中药增敏剂，与西药增敏剂进行了对照研究，探讨了其对卵巢颗粒细胞功能的影响。
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| 关 键 词： | 卵巢颗粒细胞 胰岛素抵抗 地塞米松 生殖 中药 |
| 文章编号： | 1000-7857(2008)09-0037-05 |
| 修稿时间： | 2008年3月25日 |
Beneficial Effect of Berberine and Daidzein on Insulin Resistance in Ovarian Granulose Cells Induced Dexmethasone |
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| YAO Jingping,QIU Xuemin,GAO Lei,WU Xiaoke,HOU Lihui,NI Yanqun.Beneficial Effect of Berberine and Daidzein on Insulin Resistance in Ovarian Granulose Cells Induced Dexmethasone[J].Science & Technology Review,2008,26(9):37-41. |
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| Authors: | YAO Jingping QIU Xuemin GAO Lei WU Xiaoke HOU Lihui NI Yanqun |
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| Abstract: | Ovarian granulosa cells from porcine follicles were isolated and cultured in vitro for determination of the insulin resistance,by expressions of insulin signal molecules and gonadotropin-releasing hormone signal transduction,and to establish the relations between glucose metabolic disorders and reproductive dysfunction in polycystic ovary syndrome.A comparison was made between insulin-sensitizing western medicines and two traditional Chinese medicines berberine(Ber) and daidzein(Dai) in their improvement effects on insulin sensitivity,and the effects on function of the ovarian granulose cells. |
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| Keywords: | ovarian granulose cell insulin resistance dexmethasone reproduction traditional Chinese medicine |
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