四氯化碳致大鼠肝纤维化动物模型的文献再评价

目的 通过相关文献阅读分析,比较目前利用四氯化碳(CCl4)诱导肝纤维化的造模方法,制订出最佳的造模方案,为科学研究提供参考借鉴.方法 计算机检索数据库(中国知网、万方数据知识服务平台、维普网)获取近五年相关文献,选取实验病理结果和血清学检查谷丙转氨酶(ALT)、谷草转氨酶(AST)对文献进行评分.对相关实验影响因素做...

Re-evaluation of Literature on Rat Liver Fibrosis Animal Model Induced by Carbon Tetrachloride

Abstract:To compare the current method of liver fibrosis in rats induced by tetrachloromethane, and to establishthe best method of liver fibrosis in order to provide reference for scientific research. Method Cnki, Wanfang dataand cqvip were used to search and obtain the related literatures, data and the experimental pathological results and serological examination were selected, the literature was graded according to pathology and Alanine transaminase and aspartate transaminase rates. The relevant experimental factors are evaluated, and then the criteria of modelinduction are established. Result In the model group, the normal hepatic lobule structure was destroyed and theinterlobular fibrous septum was formed. The serum ALT and AST indexes were significantly increased.Conclusion The reliable experimental scheme of hepatic fibrosis model induced by tetrachloromethane oil isreliable. species, sex, pathway of drug action and concentration of CCl4 all influence the experimental result.