猪肠系膜上动脉血栓模型建立的改良方法

摘要:目的 建立急性肠系膜上动脉栓塞动物模型,评估自主研发的取栓器取栓治疗效果。 方法 体外制作动物自体血凝块,采用介入方法将自体血凝块注入肠系膜上动脉,造成动脉栓塞,使用取栓器进行取栓。 结果 实验猪均成功建立急性肠系膜上动脉栓塞致肠缺血模型,与传统方法相比更贴近临床实际情况。 结论 采用本实验方法可成功建立可用于后续取栓治疗研究的急性肠系膜上动脉栓塞动物模型,更好的模拟临床上发病患者的栓塞情况。

Improved Method for Establishment of Porcine SuperiorMesenteric Artery Thrombosis Model

Abstract: Objective An animal model of acute superior mesenteric artery embolism was established to evaluatethe effect of self-developed thrombectomy and thrombectomy. Method Animal autologous blood clots were prepared in vitro. Interventional method were used to inject autologous blood clots into the superior mesenteric artery, resulting in arterial embolism. Embolization was performed using a thrombectomy device. Result Laboratory pigs successfully established acute intestinal ischemia-induced intestinal ischemia models, which are closer to the actual clinical situation than traditional method. Conclusion Using this experimental method, an animal model of acute superior mesenteric arterial embolism suitable for follow-up thrombectomy can be successfully established, which can better simulate the embolism of clinically-onset patients.