咳嗽变异性哮喘病理机制及造模方法的研究进展

摘要:咳嗽变异性哮喘( cough variant asthma,CVA)是一种类型比较特殊的哮喘,慢性咳嗽的主要病因之一。 目前,很多学者认为 CVA 是典型哮喘的前体疾病或是典型哮喘在气道炎症比较轻微状态下的一种过渡性表现,30% 的CVA 可能会演变成为典型哮喘。 因此,CVA 的早期发现、早期治疗就显得尤为重要,目前 CVA 发病机制尚不明确,深入研究已成为较为重要的方向,基于 CVA 模型的动物实验数目众多,但方法不尽相同,本文就咳嗽变异性哮喘的病理改变及近十年来造模方法的不同进行归纳综述。

Research Progress on the Pathological Mechanism and Modeling Methods of Cough Variant Asthma

Abstract:Cough variant asthma ( CVA) is a special type of asthma, one of the main causes of chronic cough. At present, many scholars believe that CVA is a precursor disease of typical asthma or a transitional manifestation of typical asthma when airway inflammation is relatively mild. There is 30% of CVA may evolve into typical asthma. Therefore, early detection and early treatment of CVA are particularly important. At present, the pathogenesis of CVA is not clear. In-depth research has become a more important direction. There are many animal experiments based on CVA models, but the method are not the same. This article focuses on cough variation. The pathological changes of asthma and the different modeling method in the past ten years are summarized.