| 氨基甲酸酯型石胆酸裂口分子的手性识别性能研究 |
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| 引用本文： | 赵志刚.氨基甲酸酯型石胆酸裂口分子的手性识别性能研究[J].西南民族学院学报(自然科学版),2009,35(3):522-525. |
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| 作者姓名： | 赵志刚 |
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| 作者单位： | 西南民族大学化学与环境保护工程学院。四川成都610041 |
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| 基金项目： | 四川省应用基础研究项目（04JY029-003-08）. |
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| 摘 要： | 用差紫外光谱滴定法考察了新型裂口分子1-3对D／L-氨基酸甲酯的手性识别性能，测定了主客体间的结合常数（kα）和自由能变化（△G°）．结果表明，裂口分子主体对所考察的客体分子显示良好的手性识别作用，其对D-氨基酸甲酯的识别优于对L-氨基酸甲酯的识别，识别作用的主要推动力为氢键，范德华力等的协同作用．讨论了主体与客体间形状、大小匹配和几何互补等因素，对形成超分子配合物的影响，并利用计算机分子模拟作为辅助手段对实验结果与现象进行了解释．
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| 关 键 词： | 分子识别 石胆酸 裂口分子:差紫外光谱法 |
Studies on the enantioselective recognition of carbamate-type molecular clefts derived from lithocholic acid |
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| ZHAO Zhi-gang.Studies on the enantioselective recognition of carbamate-type molecular clefts derived from lithocholic acid[J].Journal of Southwest Nationalities College(Natural Science Edition),2009,35(3):522-525. |
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| Authors: | ZHAO Zhi-gang |
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| Institution: | ZHAO Zhi-gang (School ＆Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, P. R. C.) |
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| Abstract: | Enantioselective recognition properties of three new chiral molecular clefts for amino acid methyl esters have been investigated by UV-vis spectra titration in CHCl3 at 25°C. The results indicate that molecular clefts not only recognize all amino acid methyl esters examined, but also possess higher selectivity for D-amino acid methyl esters. The drive forces come mainly from hydrogen bond and van der Waals interaction. The recognition ability and selectivity are discussed from the viewpoint of the size/shape-fit and geometrical complementary relationship between the molecular tweezers and amino acid methyl esters. |
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| Keywords: | molecular recognition lithocholic acid molecular cleft Uv-vis spectral titration |
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