Three for T: molecular analysis of the low voltage-activated calcium channel family |
| |
Authors: | E Perez-Reyes |
| |
Institution: | Department of Physiology, Loyola University Medical Center, Maywood, Illinois 60153, USA. eperez@luc.edu |
| |
Abstract: | Despite the wealth of information on voltage-gated calcium channels, little is known about low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to selectively block T-type channels has generated much interest in their structure, physiology and pharmacology. This review covers the cloning of a new family of calcium channels, their putative structure, the electrophysiological evidence that demonstrated that these complementary DNAs encoded low voltage-activated, T-type channels, the tissue expression of these genes, and concludes with a discussion of their possible physiological roles. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|