| 生物结构自组装 |
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| 引用本文： | 张先恩.生物结构自组装[J].科学通报,2009,54(18):2682-2690. |
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| 作者姓名： | 张先恩 |
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| 作者单位： | 科学技术部基础研究司;中国科学院武汉病毒研究所; |
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| 摘 要： | 生物大分子、复合物分子机器、细胞器、完整细胞乃至生命个体的形成, 自组装贯穿其中, 并有极其复杂的调控机制. 本文归纳分析了生物结构自组装的特点及其物理、化学和几何学原理, 并以新生肽链折叠和染色体折叠浓缩为例描述自组装的生物调控原理. 采用自组装策略, 已经开发了许多生物纳米功能结构, 如DNA平面和立体结构、DNA马达、蛋白纳米线、荧光双分子互补系统等. 研究复杂生物体系的自组装极具挑战, 可使我们更接近生命的本质, 还将为纳米科学技术和仿生学提供许多启示.
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| 关 键 词： | 生物结构 自组装 生物调控 纳米结构 纳米科学技术 |
| 收稿时间： | 2009-07-27 |
Self-assembly of biological structures |
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| Zhang Xian-En, Basic Research.Self-assembly of biological structures[J].Chinese Science Bulletin,2009,54(18):2682-2690. |
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| Authors: | Zhang Xian-En Basic Research |
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| Institution: | Zhang Xian-En1,2 1 Basic Research Department,Ministry of Science , Technology,Beijing 100862,China,2 Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071 |
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| Abstract: | The formation of all biological structures, from single proteins, protein complex machines, cellular organelles, whole cells to intact organisms is driven by self-assembly with very complicated bio-regulatory mechanisms. In this review, characteristics of biological self-assembly and its physical, chemical and geometrical principles are summarized, and the bio-regulatory mechanisms of self-assembly are demonstrated by taking nascent peptide folding and chromosome condensation as examples. In recent years, p... |
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| Keywords: | self-assembly biological structures bio-regulatory nanostructures nanotechnology |
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