| 慢性阻塞性肺疾病痰白细胞介素-16的测定及其意义 |
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| 引用本文： | 钟小宁,柳广南,陆光润,邓静敏,邓家珍. 慢性阻塞性肺疾病痰白细胞介素-16的测定及其意义[J]. 广西科学, 1999, 6(3): 208-209 |
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| 作者姓名： | 钟小宁 柳广南 陆光润 邓静敏 邓家珍 |
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| 作者单位： | 广西医科大学第一附属医院呼吸内科,南宁市滨湖路6号,530021 |
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| 摘 要： | 收集１９例急性期慢性阻塞性肺疾病者，６例ＣＯＰＤ缓解期患者以及１０例正常对照者的痰液，以酶联免疫吸附法测定其痰液白细胞介素－１６水平，以探讨ＩＬ－１６在ＣＯＰＤ发病机制中的作用及其对ＣＯＰＤ气道为症的临床意义。结果，ＣＯＰＤ患者急性发作期痰ＩＬ－１６水平和缓解期均明显高于正常对照者。
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| 关 键 词： | 慢性阻塞性肺疾病 白细胞介素16 气道炎症 |
| 收稿时间： | 1999-01-08 |
Significance of Detecting Interleukin-16 in Induced Sputum from Patiens with Chronic Obstructive Pulmonary Disease |
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| Zhong Xiaoning,Liu Guangnan,Lu Guangrun,Deng Jingmin and Deng Jiazhen. Significance of Detecting Interleukin-16 in Induced Sputum from Patiens with Chronic Obstructive Pulmonary Disease[J]. Guangxi Sciences, 1999, 6(3): 208-209 |
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| Authors: | Zhong Xiaoning Liu Guangnan Lu Guangrun Deng Jingmin Deng Jiazhen |
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| Affiliation: | Department of Respiratory, First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China,Department of Respiratory, First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China,Department of Respiratory, First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China,Department of Respiratory, First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China and Department of Respiratory, First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China |
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| Abstract: | In order to explore the role of interleukin-16(IL-16) in the pathogenesis of chronic obstructive pulmonary disease(COPD), and to evaluate the clinical values of IL-16 in the airway inflammation of COPD, IL-16 levels of induced sputum from 19 patients with acute COPD, 6 patients with stable COPD and 10 normal subjects were detected by ELISA method. The results showed that IL-16 levels of induced sputum in patients with acute COPD (1233±492.44 ng/L) and with stable COPD(1232±513.53 ng/L) were much higher than that in normal subjects(660.77±312.11 ng/L) (P<0.05). In addition, there was a negative correlation between IL-16 of induced sputum and FEV1 (r=-0.43,P<0.05).Our findings indicate that IL-16 could be involved in the airway inflammation process of COPD by activating T lymphocytes. |
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| Keywords: | chronic obstructive pulmonary disease interleukin 16 airway inflammation |
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