Effect of synthetic polynucleotides on the growth of transplantable tumours in BALB/c mice |
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Authors: | A. Pugliese G. Cavallo |
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Affiliation: | (1) Department of Microbiology, School of Medicine, Oniversity of Turin, via Santena 9, I-10126 Torino, (Italy) |
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Abstract: | Summary The effect of BALB/c mice pretreatment with tumour cells (a mammary adenocarcinoma, ADK-1t and an IgA secreting plasmocytoma, MOPC-315) adsorbed with poly I:C, poly I and poly C is examined. Only mice pretreated with cells of both tumours adsorbed with poly I:C and poly C proved to be extensively protected against challenge by homologous untreated tumour cells, whereas this was not so in the case of poly I. A possible explanation of this phenomenon is discussed.This work was supported by a research contract with the Italian National Research Council (C.N.R.). |
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