Allergic reactions,cyclic AMP and histamine release |
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| Authors: | P. Stahl Skov A. Geisler R. Klysner S. Norn |
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| Affiliation: | (1) Department of Pharmacology, University of Copenhagen, 20, Juliane Maries Vej, DK-2100 Copenhagen Ø, Denmark |
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| Abstract: | Summary Both isobutylmethylxantine and theophylline increased the level of cyclic AMP in the mast cell. Theophylline reduced the allergic histamine release, whereas isobutylmethylxynthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is too simple.This work was supported by grants from the Danish Medical Research Council (Grant No. 512-5270) and from Lundbeckfonden. |
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