Synsthesis and RES-stimulating activity of bacterial cell-wall peptidoglycan peptides related to FK-156 |
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| Authors: | Y Kitaura H Takeno M Aratani S Okada S Yonishi K Hemmi O Nakaguchi M Hashimoto |
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| Institution: | (1) Central Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 2-1-6, Kashima, Yodogawa-ku, 532 Osaka, (Japan) |
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| Abstract: | Summary The bacterial cell-wall peptidoglycan peptides and related compounds coupled with some fatty acids were synthesized, and their immunostimulating property was examined by carbon clearance assay. All the new compounds (2–6) proved to possess significant potencies superior to that of FK-156 (1).Acknowledgment. We are grateful to Dr J. Mori and his coworkers for the biological assays. |
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