环氧合酶-2在大肠癌组织中的表达及临床意义的研究

目的探讨COX-2蛋白在大肠癌中的表达与肿瘤发生发展和转移的关系.方法应用免疫组化SP法检测COX-2蛋白在66例大肠癌及22例正常大肠组织的表达情况.结果COX-2蛋白在66例大肠癌组织中高表达(56/66),阳性表达率84.8%,与正常大肠组织相比差异有显著性(P<0.01);COX-2蛋白的表达与肿瘤组织的浸润深度显著相关(P<0.05);与Dukes分期呈正相关(P<0.05);淋巴结有转移组与无转移组差异有显著性(P<0.05).结论COX-2在大肠癌的发生、发展及浸润、转移过程中发挥着重要作用,可望成为预测大肠癌恶性潜能的临床指标之一.

Expression and Clinical Significance of COX-2 in Colorectal Carcinoma

Objective To investigate the expression of COX-2 in a series of colorectal neoplasm and its relation to the development of colorectal carcinoma.Methods The immunohistochemical staining with SP method was used to detect the COX-2 expression in paraffin sections from 66 patients with colorectal carcinoma,22 normal mucosal tissues.Results The positive rate of COX-2(84.8%)in colorectal carcinoma was significantly higher than that in normal mucosal tissues(P<0.01);The expression of COX-2 is significantly correlated to depth of invasion(P<0.05) and Dukes stage(P<0.05),and is much higher in tumor tissue with positive-node than that with negative-node(P<0.05).Conclusion COX-2 might play a key role in the occurrence and development of invasion and metastasis in colorectal carcinoma.Overexpression of COX-2 may serve as a valuable predictor for tumor metastatic potential in colorectal carcinoma.