专利中药复方治疗肝纤维化的用药规律及机制研究

Medication regularity and mechanism of patented Chinese herbal compounds in treatinghepatic fibrosis

Objective To analyze the medication regularity and mechanism of patented Chinese herbal compounds in treating hepatic fibrosis by using the methods of data mining and network pharmacology. Methods The patent compounds of traditional Chinese medicine for the treatment of hepatic fibrosis in the China Patent Announcement Network of the State Intellectual Property Office was searched, and the database was established after screening and sorting. Microsoft Excel software and traditional Chinese medicine inheritanceplatform were used to conduct data mining and analysis on the medication rules of traditional Chinese medicine compound.To explore the mechanism of core high-frequency drug pairs in the treatment of hepatic fibrosis by network pharmacology. Results Finally, 147 patent compounds were selected for the treatment of liver fibrosis, involving 431 kinds of traditional Chinese medicine. There are Huangqi, Danshen, Biejia, Danggui and other high frequency Chinese medicine. The main effect of these drugs is to replenish deficiency, promote blood stasis and clear heat. Huangqi-Danshen is core high-frequency drug pair that treat hepatic fibrosis through active ingredients such as quercetin, luteolin, kaempferol and tanshinone IIA. MYC, STAT3, AKT1, ESR1, FOS, HIF1A, TP53 and MAPK14 are major therapeutic targets. It mainly involves PI3K-Akt, AGE-RAGE, TNF, IL-17, HIF-1, Th17 cell differentiation signal and other pathways. Conclusion The patented Chinese herbal compounds for the treatment of hepatic fibrosis are mainly tonic drugs, blood-activating and stasis-resolving drugs and heat-clearing drugs. Huangqi-Danshen is used to treat hepatic fibrosis through multi-component, multi-target and multi-pathway.