Follicles in pregnant rat ovary are incapable of steroidogenesis |
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Authors: | Yijun Chen Hongjuan Gao Yixun Liu |
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Institution: | (1) State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China |
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Abstract: | Antral follicles are present in the ovaries throughout gestation. These follicles are “physically immature” and cannot ovulate
under the induction of LH/hCG. The purpose of the present study is to examine whether follicles in pregnant rat ovaries are
capable of steroidogenesis. StAR is believed to be the key regulator of steroid hormone biosynthesis. Antisense StAR probe
and anti-StAR rabbit serum have been used to detect the StAR expression in ovarian follicles at various stages of pregnant
rats. The results indicate that theca-interstitial cells and the membrane granulosa cells at the stages from the estrous or
pre-estrous in the normal cycling rat ovary express StAR mRNA and its protein, whereas neither granulosa cells nor the theca
cells in pregnant ovary throughout gestation express StAR. These results indicate that the pregnant follicles throughout gestation
are incapable of steroidogenesis. |
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Keywords: | follicles in pregnant ovary steroidogenic acute regulatory protein luteinizing hormone receptor in situ hybridization |
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