| Spatial Memory Deficit and Tau Hyperphosphorylation Induced by Inhibiting PP2A in Rat Brain |
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| 作者姓名： | TIAN Qing ZHENG Hong-yun CHEN Juan Hong-lian GONG Cheng-xin WANG Jian-zhi |
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| 作者单位： | [1]Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China [2]Medical College, Huangshi College of Technology, Huangshi 435003, Hubei,China [3]The New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA |
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| 基金项目： | Supported by the National Natural Science Foundation of China （30370560, 39925012, 30100057, 30170221 ） and a Grant from the Li Foundertion, USA |
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| 摘 要： | Hyperphosphorylation of Tau in Alzheimer＇s disease （AD） brain appears to be caused by a down-regulation of protein phospbatase 2A （PP2A）. In this study, we selectively inhibited PP2A by injection of okadaic acid （OA） into the Meynert nucleus basalis of rats and found that 0.4 pmol of OA injeetion induced approximately 60% inhibition of PP2A 24 h after injection, 13% inhibition 48 h after injection and no obvious inhibition 72 h after injection. Hyperphosphorylation of Tau at Ser-198/ Ser-199/Ser-202 and Ser-396/Ser-404 and spatial memory deficit of rats were induced 24 h after 0. d prnol of OA injection. This study suggests that a dowreregulation of PP2A may underlie almormal hyperphosphorylation of cytoskeletal proteins leading to neurofibrillary degeneration in AD.
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| 关 键 词： | 空间记忆 老鼠 脑功能 动物实验 PP2A 抑制作用 |
| 文章编号： | 1007-1202（2005）06-1030-05 |
| 收稿时间： | 2004-11-13 |
Spatial memory deficit and Tau hyperphosphorylation induced by inhibiting PP2A in rat brain |
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| TIAN Qing ZHENG Hong-yun CHEN Juan Hong-lian GONG Cheng-xin WANG Jian-zhi.Spatial Memory Deficit and Tau Hyperphosphorylation Induced by Inhibiting PP2A in Rat Brain[J].Wuhan University Journal of Natural Sciences,2005,10(6):1030-1034. |
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| Authors: | Tian Qing Zheng Hong-yun Chen Juan Li Hong-lian Gong Cheng-xin Wang Jian-zhi |
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| Institution: | (1) Pathophysiology Department, Tongii Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China;(2) Medical College, Huangshi College of Technology, 435003 Huangshi, Hubei, China;(3) The New York State Institute for Basic Research in Developmental Disabilities, 10314 Staten Island, New York, USA |
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| Abstract: | Hyperphosphorylation of Tau in Alzheimer’s disease (AD) brain appears to be caused by a down-regulation of protein phosphatase
2A (PP2A). In this study, we selectively inhibited PP2A by injection of okadaic acid (OA) into the Meynert nucleus basalis
of rats and found that 0.4 pmol of OA injection induced approximately 60% inhibition of PP2A 24 h after injection, 13% inhibition
48 h after injection and no obvious inhibition 72 h after injection. Hyperphosphorylation of Tau at Ser-198/Ser-199/Ser-202
and Ser-396/Ser-404 and spatial memory deficit of, rats were induced 24 h after 0. 1 pmol of OA injection. This study suggests
that a down-regulation of PP2A may underlie abnormal hyperphosphorylation of cytoskeletal proteins leading to neurofibrillary
degeneration in AD.
Foundation item: Supported by the National Natural Science Foundation of China (30370560, 39925012, 30100057, 30170221) and a Grant from
the Li Foundation, USA
Biography: TIAN Qing (1973-), female, M. D., research direction: neuropathophysiology. |
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| Keywords: | protein phosphatase 2A Tau Alzheimer’ s disease |
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