Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci |
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| Authors: | Cookson W O Ubhi B Lawrence R Abecasis G R Walley A J Cox H E Coleman R Leaves N I Trembath R C Moffatt M F Harper J I |
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| Affiliation: | Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. william.cookson@ndm.ox.ac.uk |
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| Abstract: | We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity. |
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