| Measuring radial Young’s modulus of DNA by tapping mode AFM |
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| 引用本文： | LIN Yi SHEN XinCheng WANG JingJing BAO Lei ZHANG ZhiLing PANG DaiWen. Measuring radial Young’s modulus of DNA by tapping mode AFM[J]. 科学通报(英文版), 2007, 52(23): 3189-3192. DOI: 10.1007/s11434-007-0475-7 |
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| 作者姓名： | LIN Yi SHEN XinCheng WANG JingJing BAO Lei ZHANG ZhiLing PANG DaiWen |
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| 作者单位： | College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan 430072, China |
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| 基金项目： | Supported by the National Key Scientific Program （Grant No. 2006CB933100）, the Science Fund for Creative Research Groups of NSFC （Grant No. 20621502） and China Postdoctoral Science Foundation （Grant No. 20060400867）.The authors want to thank Mr. Bob Reutter from Agilent Technologies and Dr. Yun Wu from Wuhan University of Technology for their constructive suggestions. |
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| 摘 要： | Based on tapping mode AFM imaging, a method was demonstrated to evaluate compression elasticity of single double-stranded DNA （dsDNA） molecules in the force region. With images under ambient conditions, Young＇s moduli of dsDNA in compression were calculated. Results demonstrated that Young＇s moduli of dsDNA can be simply deduced according to the proposed model. The method can also be used to evaluate the compression elasticity of similar soft nanomaterials.
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| 关 键 词： | 测量光线 抽头模型 弹性 显微镜 |
| 收稿时间： | 2007-07-01 |
| 修稿时间： | 2007-08-03 |
Measuring radial Young’s modulus of DNA by tapping mode AFM |
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| Lin Yi,Shen XinCheng,Wang JingJing,Bao Lei,Zhang ZhiLing,Pang DaiWen. Measuring radial Young’s modulus of DNA by tapping mode AFM[J]. Chinese science bulletin, 2007, 52(23): 3189-3192. DOI: 10.1007/s11434-007-0475-7 |
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| Authors: | Lin Yi Shen XinCheng Wang JingJing Bao Lei Zhang ZhiLing Pang DaiWen |
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| Affiliation: | (1) College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan, 430072, China |
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| Abstract: | Based on tapping mode AFM imaging, a method was demonstrated to evaluate compression elasticity of single double-stranded DNA (dsDNA) molecules in the force region. With images under ambient conditions, Young’s moduli of dsDNA in compression were calculated. Results demonstrated that Young’s moduli of dsDNA can be simply deduced according to the proposed model. The method can also be used to evaluate the compression elasticity of similar soft nanomaterials. Supported by the National Key Scientific Program (Grant No. 2006CB933100), the Science Fund for Creative Research Groups of NSFC (Grant No. 20621502) and China Postdoctoral Science Foundation (Grant No. 20060400867) |
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| Keywords: | DNA Young’ s modulus elasticity atomic force microscopy |
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