Protracted analgesia in young and adult rats maternally exposed to methadone |
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| Authors: | I S Zagon Patricia J McLaughlin |
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| Institution: | (1) Department of Anatomy, The Milton S. Hershey Medical Center, The Pennsylvania State University, 17033 Hershey, Pennsylvania, USA |
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| Abstract: | Summary The analgesic response to the hot-plate test was studied in 21-, 45-, 60-, 120- and 300-day-old rats maternally exposed to methadone (5 mg/kg). An elevation in nociceptive threshold, in the absence of further exposure to methadone, was observed in young and adult rats perinatally subjected to methadone.This research was supported by grant DA 01618. |
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