| GSH对甲醛的解毒作用 |
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| 引用本文： | 罗纪盛 顾亦军. GSH对甲醛的解毒作用[J]. 华东师范大学学报(自然科学版), 1995, 0(1): 101-107 |
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| 作者姓名： | 罗纪盛 顾亦军 |
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| 作者单位： | 华东师范大学生物学系 |
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| 摘 要： | 本文以人红细胞为材料，探讨还原型谷胱甘肽（ＧＳＨ）对解除甲醛的毒作用效果，实验结果表明５ｍｍｏｌ／Ｌ甲醛处理人红细胞后，磷酸甘油醛脱氢酶（ＧＰＤＨ）发生的变化与ＧＳＨ含量的变化呈正相关，同时可滴定巯基含量变化则与Ｎａ．Ｋ－ＡＴＰ酶活力变化呈负相关。在受甲醛毒害的红细胞悬液内加入ＧＳＨ，ＧＰＤＨ活力得到恢复和提高，提示ＧＳＨ有解除甲醛毒作用的效果。
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| 关 键 词： | GSH 甲醛 红细胞 毒作用 解毒 生物化学 |
GSH Protective Action in Formaldehyde Toxicity |
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| Luo Jisheng, GU YiJun, Zhang YanPing, Shen Lan. GSH Protective Action in Formaldehyde Toxicity[J]. Journal of East China Normal University(Natural Science), 1995, 0(1): 101-107 |
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| Authors: | Luo Jisheng GU YiJun Zhang YanPing Shen Lan |
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| Affiliation: | Department of Biology. East China Normal University. Shanghai 200062 |
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| Abstract: | This study revealed that reduced gluta-thione (GSH) (concentration of ImM-4mM) induced an increase in the activity of glyceraldhyde phosphate dehydrogenase of humun erythrocyte suspended in 5mM formaldehyde. The results show a significant detoxication of GSH on human erythrocyte exposed to formaldehyde. It was also found a positive correlation between an decrease in the activity of glyceraldehyde phosphate dehydrogenase (GPDH) and GSH of erythrocyte by treatment at 5mM formaldehyde. These results support the notion that GPDH inhibition observed after formaldehyde addition is due to GSH depletion caused by formaldehyde. |
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| Keywords: | GSH GPDH Formaldehyde human erythrocyte toxic action detoxication |
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