Decreased pulmonary levels of the anti-inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmatics |
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| Authors: | Lensmar C Nord M Gudmundsson G H Roquet A Andersson O Jörnvall H Eklund A Grunewald J Agerberth B |
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| Institution: | (1) Department of Medicine, Division of Respiratory Medicine, Lung Research Laboratory, L2:01 Karolinska Hospital, S-171 76 Stockholm (Sweden), Fax +46 8 51 77 54 51, e-mail: catarinal@lung.ks.se, SE;(2) Department of Medical Nutrition, Novum, Huddinge University Hospital, S-141 86 Huddinge (Sweden), SE;(3) Microbiology and Tumorbiology Center, and, SE;(4) Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm (Sweden), SE |
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| Abstract: | The Clara cell 16 kDa protein (CC16) maps to an atopy-associated region of chromosome 11 and has been ascribed an anti-inflammatory
function. Using reverse-phase HPLC and Western blot analysis, we have evaluated the polypeptide pattern in bronchoalveolar
lavage (BAL) fluid retrieved from asthmatics, before and after induction of airway inflammation by low-dose allergen inhalation
challenge. A prominent decrease of CC16 was seen after induction of inflammation, and a further CC16 decrease was observed
in lavage fluid where surfactant had been removed. Reduced levels of pulmonary CC16 may cause loss of anti-inflammatory activity
in the airways and contribute to the development of airway inflammation in asthma.
Received 22 March 2000; received after revision 4 May 2000; accepted 4 May 2000 |
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| Keywords: | , CC16, reverse-phase HPLC, asthma, BAL fluid proteins, |
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