| 盐酸二甲双胍缓释骨架微丸的研制 |
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| 引用本文： | 谢英花,胡易,马燕山,陈卉,侯东岳,孙勇军.盐酸二甲双胍缓释骨架微丸的研制[J].河北科技大学学报,2013,34(3):224-229. |
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| 作者姓名： | 谢英花 胡易 马燕山 陈卉 侯东岳 孙勇军 |
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| 作者单位： | 河北科技大学化学与制药工程学院;石家庄市中医院 |
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| 基金项目： | 河北省高等学校科学技术研究青年基金(2010241);河北省自然科学基金(C2011208081) |
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| 摘 要： | 采用挤出滚圆造粒机制备盐酸二甲双胍缓释骨架微丸,通过单因素考察和正交设计筛选最优化处方及工艺条件,评价了微丸的粉体学性质和体外释放度。本工艺中微晶纤维素(MCC)的质量分数为10%,乙基纤维素(EC)和硬脂酸物质的量比为1∶1,黏合剂采用质量分数为2%的羟丙基甲基纤维素(HPMC K4M),在此条件下经烘干制得的盐酸二甲双胍缓释骨架微丸具有较好的缓释效果,释药动力学符合Higuchi方程,且圆整度好。本方法制备盐酸二甲双胍缓释骨架微丸工艺可靠,质量可控。
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| 关 键 词： | 盐酸二甲双胍 骨架缓释微丸 挤出滚圆法 释放度 |
| 收稿时间： | 2012/11/28 0:00:00 |
| 修稿时间： | 2013/2/26 0:00:00 |
Preparation of metformin hydrochloride
sustained-release matrix pellets |
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| XIE Yinghu,HU Yi,MA Yanshan,CHEN Hui,HOU Dongyue and SUN Yongjun.Preparation of metformin hydrochloride
sustained-release matrix pellets[J].Journal of Hebei University of Science and Technology,2013,34(3):224-229. |
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| Authors: | XIE Yinghu HU Yi MA Yanshan CHEN Hui HOU Dongyue and SUN Yongjun |
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| Institution: | 1(1.School of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China;2.Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei 050051,China) |
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| Abstract: | Metformin hydrochloride sustained-release matrix pellets are prepared by extrusion-spheronization method.The optimal operating conditions and formulation are obtained by single-factor and orthogonal experimental design.The micromeritic characteristics and the release in vitro of these pellets are evaluated.In the process,micro-crystal cellulose(MCC) is 10%,ethyl cellulose(EC)∶stearic acid=1∶1,and 2% hypromellose(HPMC K4M) is used.The profiles of the prepared sustained-release pellets follow Higuchi equation,and have good sphericity.The developed process is reliable and the quality of the pellets is controllable. |
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| Keywords: | metformin hydrochloride sustained-release matrix pellets extrusion-spheronization drug release |
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