| 准确测定发酵液中抗生素效价新方法的研究 |
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| 引用本文： | 高榕,赵越. 准确测定发酵液中抗生素效价新方法的研究[J]. 山东大学学报(理学版), 2005, 40(6): 112-116 |
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| 作者姓名： | 高榕 赵越 |
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| 作者单位： | 1. 山东胜利股份有限公司,山东,济南,250002
2. 山东大学,微生物技术国家重点实验室,山东,济南,250100 |
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| 基金项目： | 山东省自然科学基金资助项目（Y2004,B09） |
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| 摘 要： | 基于微生物对药物反应过程的动力学分析提出了一个以抑茵圈半径微分变化率为反应标准的方法．测定结果可用Gaussian分布方程得到很好的拟合．其结果受药物浓度范围影响很少，从而能得到确定的半数杀菌效价（EC50）．
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| 关 键 词： | 抗生素 效价 半数杀菌效价（EC50） |
| 文章编号： | 1671-9352（2005）06-0112-05 |
| 收稿时间： | 2005-06-08 |
| 修稿时间： | 2005-06-08 |
A novel approach for accurate estimating the potency of antibiotics in fermentative fluid |
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| GAO Rong,ZHAO Yue. A novel approach for accurate estimating the potency of antibiotics in fermentative fluid[J]. Journal of Shandong University, 2005, 40(6): 112-116 |
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| Authors: | GAO Rong ZHAO Yue |
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| Affiliation: | 1. Shandong Sheng-Li Co. Ltd, Jinan 250002, Shandong, China; 2. State Key Laboratory of Microbial Technology, Shandong Uniersity, Jinan 250100, Shandong, China |
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| Abstract: | Based on the analysis of kinetic progress of dose-response for bacteria, a new analysis method fitting dose-treatment curve using differential rates of antibiotics as a function versus antibiotic concentration was proposed, Then Gaussian equation was used for fitting data and the parameter EC50 was selected for the inhibitory capacity expression. The results obtained by this method are of stability and accuracy. |
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| Keywords: | antibiofics effectiveness EC50 |
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