The hemocompatibility and the reabsorption function of TiO2 nanotubes biomembranes

A novel high-intensity TiO₂ nanotubes array membrane was fabricated via electrochemical anodization of highly pure titanium foil and an open-ended TiO₂ nanotubes array membrane was obtained by HF gas etching at the bottom of the nanotubes. Pig tubular epithelial cells (LLC-PK1) and vascular endothelial cells (ECV304) were cultivated on the open-ended TiO₂ nanotubes surface through a mixing implantation method and TiO₂ nanotubes biomembrane materials with physiological function were successfully produced. Hemocompatibility of glass slides, pure titanium, TiO₂ nanotubes without cells and TiO₂ nanotubes with culture cells were investigated by the plasma recalcification time method and reabsorption of sodium and potassium were measured by custom-designed devices. The results show that the hemocompatibility of the TiO₂ nanotubes array membrane with culture cells was superior to the control group, and the biomembrane has an excellent reabsorption function. This demonstrates that a TiO₂ nanotubes array membrane has excellent physiological function and is an ideal candidate material for biological dialysis.