Mapping the transition state and pathway of protein folding by protein engineering |
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| Authors: | A Matouschek J T Kellis L Serrano A R Fersht |
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| Institution: | MRC Unit for Protein Function and Design, University of Cambridge, UK. |
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| Abstract: | In the transition state for unfolding of barnase, the hydrophobic core between the major alpha-helix and beta-sheet is somewhat weakened, the C terminus of the major helix is largely intact but its N terminus is exposed and a major loop has been invaded by solvent. |
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