Reshaping human antibodies for therapy |
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| Authors: | L Riechmann M Clark H Waldmann G Winter |
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| Institution: | MRC Laboratory of Molecular Biology, Cambridge, UK. |
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| Abstract: | A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes. |
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