A preliminary study on the behaviour and biochemical responses subsequent to the injection of 5,6-dihydroxy-tryptamine into the substantia nigra of the rat |
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| Authors: | N. N. Osborne V. Neuhoff K. H. Sontag S. Wolfarth |
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| Affiliation: | (1) Forschungsstelle Neurochemie and Abteilung Biochemische Pharmakologie, Max-Planck-Institut für experimentelle Medizin, D-3400 Göttingen, (Federal Republic of Germany);(2) Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, (Poland) |
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| Abstract: | Summary Injection of 5,7-dihydroxytryptamine into the substantia nigra of rats produces an increase of dopamine in the ipsilateral striatum, and when these animals are injected with amphetamine they do not exhibit any rotation. The mode of action of this neurotoxin is compared with that of 6-hydroxydopamine. |
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