Effect of enkephalins in the presence of the antibiotic bacitracin in the longitudinal muscle strip preparation from guinea-pig ileum |
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| Authors: | Amaya Aleixandre P Garcia de Jalón Isabel Martin |
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| Institution: | (1) Departmento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid 3, (Spain) |
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| Abstract: | Summary The antibiotic bacitracin (5×10–5–4×10–4 M) increases the inhibition of the contractile response caused by both enkephalin release and direct application of Met-enkephalin 5×10–7 M in the longitudinal muscle strip preparation from guinea-pig ileum. This effect is attributed to an inhibition of enkephalin degrading peptidases by bacitracin. |
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