| 多孔PTFE/PE/PP驻极体对利多卡因的小鼠皮肤通透性的促进作用研究 |
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| 引用本文： | 崔黎丽,韩冬,江键,李国栋,宋茂海,王小平,方影.多孔PTFE/PE/PP驻极体对利多卡因的小鼠皮肤通透性的促进作用研究[J].北京理工大学学报,2005,25(Z1):122-125. |
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| 作者姓名： | 崔黎丽 韩冬 江键 李国栋 宋茂海 王小平 方影 |
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| 作者单位： | 1. 第二军医大学,药学院无机化学教研室,上海,200433
2. 第二军医大学,基础部数理教研室,上海,200433 |
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| 摘 要： | 用高效液相色谱法研究了不同表面电位对利多卡因的体外小鼠皮肤通透性的促进作用.热融法制得的多孔PTFE/PE/PP驻极体膜结果表明带正、负极性的多孔PTFE/PE/PP驻极体对利多卡因均有明显的透皮促进作用;正极性多孔PTFE/PE/PP驻极体较负极性多孔PTFE/PE/PP驻极体对利多卡因有更强的皮肤促渗作用;正极性多孔PTFE/PE/PP驻极体对利多卡因的皮肤通透性随表面电位的增加而增加.
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| 关 键 词： | 驻极体 利多卡因 透皮吸收 多孔聚四氟乙烯 聚丙烯 聚乙烯 多孔 PTFE 驻极体膜 利多卡因 小鼠皮肤 通透性 促渗作用 研究 Porous Effect Study Skin Mouse Permeation Lidocaine 正极性 透皮促进作用 负极性 结果 法制 |
| 文章编号： | 1001-0645(2005)增刊-122-04 |
| 修稿时间： | 2005年6月10日 |
Study of Enhancing Effect of Porous PTFE/PE/PP Electret on Lidocaine Permeation Through Mouse Skin |
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| CUI Li-li,HAN Dong,JIANG Jian,LI Guo-dong,SONG Mao-hai,WANG Xiao-ping,FANG Ying.Study of Enhancing Effect of Porous PTFE/PE/PP Electret on Lidocaine Permeation Through Mouse Skin[J].Journal of Beijing Institute of Technology(Natural Science Edition),2005,25(Z1):122-125. |
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| Authors: | CUI Li-li HAN Dong JIANG Jian LI Guo-dong SONG Mao-hai WANG Xiao-ping FANG Ying |
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| Abstract: | The influence of porous PTFE/PE/PP electrets prepared by heat melting method with different surface potential on the transdermal delivery of lidocaine through mouse skin has been studied by using high performance liquid chromatography (HPLC). The results show that although both the negative and positive electret could promote the lidocaine transdermal delivery, the positive electret showed much higher enhancing effect than negative electret. Moreover, the enhancing effect of the positive electret on the lidocaine skin permeation raised as increasing the surface potential of the electret. |
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| Keywords: | electret lidocaine transdermal delivery porous PTFE PE PP |
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