| OPV疫苗液体剂型稳定性影响因素分析 |
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| 引用本文： | 宋霞,段维国,全文琦,黄铠,张晓丽,张云昆,谢明学,谢忠平.OPV疫苗液体剂型稳定性影响因素分析[J].云南大学学报(自然科学版),2008,30(1):98-100. |
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| 作者姓名： | 宋霞 段维国 全文琦 黄铠 张晓丽 张云昆 谢明学 谢忠平 |
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| 作者单位： | 中国医学科学院,北京协和医学院,医学生物学研究所,云南,昆明,650118 |
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| 基金项目： | 云南省科技创新人才引培项目（2002PY11）. |
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| 摘 要： | 分析了温度、反复冻融、冷链运输过程对口服脊髓灰质炎减毒活疫苗(OPV)滴度的影响,检测结果显示OPV分别在37℃条件下放置3d,25℃放置14d,-20℃放置36个月、反复冻化35次,感染性滴度均无明显变化.在冷链条件下运输,其感染性滴度无明显变化.液体剂型的稳定性优于糖丸剂型(t=3.2043,P<0.01).
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| 关 键 词： | 脊髓灰质炎病毒 减毒活疫苗 稳定性 |
| 文章编号： | 0258-7971（2008）01-0098-03 |
| 收稿时间： | 2007-04-15 |
| 修稿时间： | 2007年4月15日 |
Stabilities of live attenuated oral poliomyelitis vaccine |
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| SONG Xia,DUAN Wei-guo,QUAN Wen-qi,HUANG Kai,ZHANG Xiao-li,ZHANG Yun-kun,XIE Min-xue,XIE Zhong-ping.Stabilities of live attenuated oral poliomyelitis vaccine[J].Journal of Yunnan University(Natural Sciences),2008,30(1):98-100. |
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| Authors: | SONG Xia DUAN Wei-guo QUAN Wen-qi HUANG Kai ZHANG Xiao-li ZHANG Yun-kun XIE Min-xue XIE Zhong-ping |
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| Institution: | Chinese Academy of Medical Sciences, Peking Union Medical College, Institute of Medical Biology, Kunming 650118, China |
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| Abstract: | The influences of temperature,freezing and melting repeatedly and cold-chain transportation on oral polio vaccine(OPV) were analyzed.The results indicated that the titers of OPV had no obvious changes after being put at 37 ℃ for 3 days,25 ℃ for 14 days and-20℃ for 36 months,and being freezed and melted for 35 times,respectively.The titers had no obvious changes under the cold-chain transportation.The stability of the liquid form is better than the dragee candy form(t=3.204 3,P<0.01). |
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| Keywords: | poliomyelitis virus live attenuated vaccine stability |
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