| 2,3,5-三甲基-5,6-二氢吡嗪脱氢芳构化研究 |
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| 引用本文： | 唐巧华,李谦和.2,3,5-三甲基-5,6-二氢吡嗪脱氢芳构化研究[J].湖南师范大学自然科学学报,2009,32(4). |
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| 作者姓名： | 唐巧华 李谦和 |
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| 作者单位： | 湖南师范大学精细催化合成研究所,中国长沙,410081 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 介绍以丁二酮和1,2-丙二胺为原料,经缩合、脱氢芳构化反应合成2,3,5-三甲基吡嗪的新方法.重点考察了脱氢剂组成、脱氢剂用量、溶剂用量等对反应的影响.确定了合成2,3,5-三甲基吡嗪的优化条件为:以无水乙醇为溶剂,投料比为丁二酮:丙二胺:脱氢剂:无水乙醇=1:0.67:1.4:1.31(质量比);缩合反应温度为20～25℃:回流脱氢4 h,2,3,5-三甲基吡嗪的含量达98%以上.
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| 关 键 词： | 5-三甲基吡嗪 丁二酮 2-丙二胺 脱氢芳构化 |
Studies on Dehydroaromalization of 2,3,5-Trimethyl-5,6-Dihydropyrazine |
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| TANG Qiao-hua,LI Qian-he.Studies on Dehydroaromalization of 2,3,5-Trimethyl-5,6-Dihydropyrazine[J].Journal of Natural Science of Hunan Normal University,2009,32(4). |
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| Authors: | TANG Qiao-hua LI Qian-he |
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| Abstract: | A novel method introduce to synthesis 2,3,5-trimethylpyrazine by consendation of biacetyl and 1,2-diaminopropane followed by dehydroarmatization was studied.The composition of dehydrogenation oxidizer.the amount of dehydrogenation oxidizer and solvent were investigated emphatically.The optimum conditions were established as follow:anhydrous ethyl alcohol as solvent,the ratio of biacetyl,1,2-diaminopropane,dehydrogenation oxidizer and solvent is 1:0.67:1.4:1.31(by weight),condensation at 20～25℃,and dehydrogenation at refluxing temperature of ethyl alcohol for 4 h,2,3,5-trimethylpyrazine can be obtained with 98%purity. |
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| Keywords: | 2 3 1 2 3 5-trimethylpyrazine biacetyl 1 2-diaminopropane dehydroaromatization |
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