T-cell co-stimulation through B7RP-1 and ICOS |
| |
Authors: | Yoshinaga S K Whoriskey J S Khare S D Sarmiento U Guo J Horan T Shih G Zhang M Coccia M A Kohno T Tafuri-Bladt A Brankow D Campbell P Chang D Chiu L Dai T Duncan G Elliott G S Hui A McCabe S M Scully S Shahinian A Shaklee C L Van G Mak T W Senaldi G |
| |
Institution: | Amgen Inc., Thousand Oaks, California 91320, USA. syoshina@amgen.com |
| |
Abstract: | T-cell activation requires co-stimulation through receptors such as CD28 and antigen-specific signalling through the T-cell antigen receptor. Here we describe a new murine costimulatory receptor-ligand pair. The receptor, which is related to CD28 and is the homologue of the human protein ICOS, is expressed on activated T cells and resting memory T cells. The ligand, which has homology to B7 molecules and is called B7-related protein-1 (B7RP-1), is expressed on B cells and macrophages. ICOS and B7RP-I do not interact with proteins in the CD28-B7 pathway, and B7RP-1 co-stimulates T cells in vitro independently of CD28. Transgenic mice expressing a B7RP-1-Fc fusion protein show lymphoid hyperplasia in the spleen, lymph nodes and Peyer's patches. Presensitized mice treated with B7RP-1-Fc during antigen challenge show enhanced hypersensitivity. Therefore, B7RP-1 exhibits co-stimulatory activities in vitro and in vivo. ICOS and B7RP-1 define a new and distinct receptor-ligand pair that is structurally related to CD28-B7 and is involved in the adaptive immune response. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|