Enantioselective benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes |
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| Authors: | XueLiang Huang Song Ye |
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| Affiliation: | Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China |
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| Abstract: | Benzoin condensation is an important carbon-carbon bond-forming reaction. The benzoin reaction with good yield, high enanti-oselectivity and broad substrate scope is highly desired in organic synthesis. The intermolecular benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes has been investigated, and the corresponding α-hydroxyketones were obtained with yields up to 76% and enantioselectivities up to 99% ee. |
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| Keywords: | asymmetric catalysis benzoin condensation bifunctional N-heterocyclic carbene &alpha -hydroxyketones |
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