| 红豆杉细胞悬浮培养及动力学研究 |
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| 引用本文： | 梅兴国,鲁明波,余龙江,戴奇雷. 红豆杉细胞悬浮培养及动力学研究[J]. 华中科技大学学报(自然科学版), 1997, 0(2) |
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| 作者姓名： | 梅兴国 鲁明波 余龙江 戴奇雷 |
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| 作者单位： | Mei Xingguo Prof.; Dept. of Bioengin.，HUST，Wuhan 430074，China. Lu Mingbo Yu Longjiang Dai Qilei |
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| 基金项目： | 国家“八五”科技攻关重点资助 |
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| 摘 要： | 对红豆杉细胞在５Ｌ通气机械搅拌式反应器中的培养过程及动力学进行了研究．经２４ｄ培养，细胞生物量增加３倍，紫杉醇含量可达细胞干重的１．０３５×１０－３．建立了描述细胞生长过程的模型，采用分段多项式函数逼近关联ｕ与ｕｍ的函数Ｆ（ｓ），建立了描述产物合成的动力学方程，采用多项式函数逼近关联产物合成速率与细胞生长速率的函数，确定了部分动力学参数
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| 关 键 词： | 紫杉醇；红豆杉细胞悬浮培养；动力学 |
Taxus Cell Suspension Culture and Metabolic Kinetics |
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| Mei Xingguo Prof., Dept. of Bioengin.,HUST,Wuhan ,China. Lu Mingbo Yu Longjiang Dai Qilei. Taxus Cell Suspension Culture and Metabolic Kinetics[J]. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY.NATURE SCIENCE, 1997, 0(2) |
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| Authors: | Mei Xingguo Prof. Dept. of Bioengin. HUST Wuhan China. Lu Mingbo Yu Longjiang Dai Qilei |
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| Affiliation: | Mei Xingguo Prof., Dept. of Bioengin.,HUST,Wuhan 430074,China. Lu Mingbo Yu Longjiang Dai Qilei |
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| Abstract: | The metabolic kinetics of the Taxus cell suspension culture in a bioreactor including the cell growth curve, the sugar con sumption curve, the [PO 3- 4] consumption curve, the pH curve and protein contents curve, and the taxol contents in cells curve have been investigated. A model with a new function for describing the cell growth is developed. Some parameters have been determined. |
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| Keywords: | Taxol cell suspension culture metabolic kinetics |
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