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Mechanism of human immunodeficiency virus type I entry into the target cells |
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| Authors: | CHEN Yinghu XIAO Yi Manfred P. Dierich |
| Affiliation: | Laboratory of Immunology, School of life Science and Engineering, Tsinghua University, Beijing 100084, China,Laboratory of Immunology, School of life Science and Engineering, Tsinghua University, Beijing 100084, China,Institute of Hygiene, University of Innsbruck, Ludwig-Boltzmann-Institute for AIDS-Research, A-6020 Innsbruck, Austria |
| Abstract: | Based on the recent advances of the research on the mechanism of HIV-1 infection, a novel model to elucidate the mechanism of HIV entry into the target cells is proposed and the perspective about the putative receptor is discussed in this review. Understanding of the crystal structure of HIV-1 transmembrane protein gp41 and the functions of HIV-1 receptor, co-receptor and the putative receptor will lead to developing effective HIV vaccine and anti-HIV drugs. |
| Keywords: | HTV-1 receptor envelope protein HTV entry target cells. |
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