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| Molecular mechanism of abnormal aggregation of α-synuclein | |
| 作者姓名： | HU HongYu & LIN XiaoJing State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China |
| 作者单位： | HU HongYu & LIN XiaoJing State Key Laboratory of Molecular Biology，Institute of Biochemistry and Cell Biology，Shanghai Institutes for Biological Sciences，Chinese Academy of Sciences，Shanghai 200031，China |
| 基金项目： | the National Natural Science Foundation of China (Grants Nos. 39990600 and 30570377)，the Chinese Academy of Sciences (Grant Nos. STZ97-2-02 and KSCX2-SW-209)，the Shanghai Commission of Science and Technology (Grant Nos. 98QA14017 and 03JC14081) |
| 摘 要： | The abnormal aggregation of α-synuclein (α-Syn) is thought to be closely associated with Parkinson's disease, but the pathogenesis is still unclear. In this review, we survey the latest development in the molecular mechanism of abnormal α-Syn aggregation, especially in the aspects of the core sequences, aggregation inhibitors, structural transformation and filament morphologies. By exploring the mecha-nism of α-Syn aggregation, we will have a better understanding of the disease pathogenesis, and de-velop strategies for preventing and treating this severe disease. |
| 关 键 词： | α-synuclein aggregation molecular mechanism Parkinson's disease |
| 收稿时间： | 2006-07-24 |
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