Gastric mucus effusion elicited by oral copper compounds: Potential anti-ulcer activity

Summary In rats, both Cu(I) and Cu(II) show an irritancy profile not shared with Cu^o or Zn(II) or Ni(II). The gastric response to Cu(II), i.e. copius fluid and mucus secretion, can protect the stomach from the acute ulcerative effects of aspirin or physical stress administered subsequently.to whom all enquiries should be addressed, Supported by grants from the National Health and Medical Research Council (Austr.) and University of Tasmania Research Commitee.Acknowledgments: ProfessorsW. R. Walker (Newcastle, Austr.) andL. Field (Nashville, Tenn.) for gifts of Cu(I) and Zn complexes;Dr. J. R. J. Sorenson (Cincinnatti, Ohio) for illuminating discussion; Drs.D. D. Perrin (Canberra) andR. P. Agarwal (Washington D. C.) for providing stability constants and much helpful advice.