Rate of tryptophan hydroxylation in vivo in brain nuclei of genetically hypertensive rats of the Lyon strain |
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| Authors: | L Denoroy M L Tappaz R Fety M Vincent B Renaud J Sassard |
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| Institution: | (1) Département de Physiologie et Pharmacologie Clinique, ERA CNRS 894, Faculté de Pharmacie, avenue Rockefeller, F-69373 Lyon Cédex 08, (France);(2) Groupe de Neurochimie Fonctionnelle, INSERM U 171, avenue Rockefeller, F-69373 Lyon Cédex 08, (France);(3) Laboratoire de Physiologie, Faculté de Médecine Grange Blanche, 8, avenue Rockefeller, F-69373 Lyon Cédex 08, (France) |
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| Abstract: | Summary The rate of tryptophan hydroxylation in vivo is unaltered in brain areas of 5, 9 and 21 week-old Lyon genetically Hypertensive (LH) rats as compared to both Lyon Normotensive (LN) and Low Blood Pressure (LL) rats, except for a decrease in the C1 area of the medulla oblongata in 9 week-old animals.Acknowledgment. The authors wish to thank Dr M.F. Belin, Dr J.F. Pujol and Mrs J. Sacquet for their help during this study. This work was supported by the Fondation pour la Recherche Médicale Française and the C.N.R.S. |
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| Keywords: | Genetically hypertensive rats serotonin synthesis tryptophan hydroxylase |
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