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| 抗小儿腹泻中药复方宝泻宁提取工艺的优化研究 | |
| 引用本文： | 刘静,周盈利,王婵娟,徐月红,张克坚,王冬梅. 抗小儿腹泻中药复方宝泻宁提取工艺的优化研究[J]. 中山大学学报(自然科学版), 2015, 54(2): 101-105 |
| 作者姓名： | 刘静 周盈利 王婵娟 徐月红 张克坚 王冬梅 |
| 作者单位： | 1. 中山大学药学院，广东 广州 510006; 2. 广东华南新药创制中心， 广东 广州 510663； 3. 广东省现代中药工程技术研究开发中心，广东 广州 510006 |
| 基金项目： | 广东省重大科技计划资助项目(2010A080813002) |
| 摘 要： | 为优化并建立抗小儿腹泻中药复方宝泻宁(BXN)的提取工艺,采用回流提取法,以吴茱萸碱、吴茱萸次碱、丁香酚、桂皮醛的转移率为考察指标,选择不同浓度乙醇为提取溶媒,选定溶媒含醇量、料液比、提取时间、提取次数为考察因素,采用L9(34)正交表进行BXN的提取工艺的优化。综合考虑各指标成分转移率及工业应用的方便、经济,经工艺验证,选定采用10倍量的φ=95%乙醇回流提取2次,每次提取2 h为优选工艺,该方法可有效提取BXN中的有效成分,4个指标成分的转移率均在80%以上,并具有稳定、经济、便捷的优点。 |
| 关 键 词： | 中药复方BXN 抗腹泻 提取 正交试验 |
Optimization of Extraction Process of Chinese Herbal Compound Bao-Xie-Ning for Anti-Diarrhea in Infant |
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| LIU Jing,ZHOU Yingli,WANG Chanjuan,XU Yuehong,ZHANG Kejian,WANG Dongmei. Optimization of Extraction Process of Chinese Herbal Compound Bao-Xie-Ning for Anti-Diarrhea in Infant[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2015, 54(2): 101-105 | |
| Authors: | LIU Jing ZHOU Yingli WANG Chanjuan XU Yuehong ZHANG Kejian WANG Dongmei |
| Affiliation: | 1.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006,China; 2. South China Center for Innovative Pharmaceuticals, Guangzhou 510663,China； 3. Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou 510006,China |
| Abstract: | The study is to optimize and establish the extraction process of the Chinese herbal Compound Bao Xie Ning used for Anti diarrhea in Infant. The process was optimized by taking the extraction percentages of evodiamine, rutaecarpine, eugenol, cinnamic aldehyde as the evaluation parameters, considering the concentration of ethanol (extraction solvent), liquid solid ratio, extraction time, extraction times as the affecting factor, and the extraction process of BXN optimized by L9 (34) orthogonal design. The results show that optimum condition is achieved when the concentration of ethanol is 95%, liquid-solid ratio is 10 (V/m), the mixed herbs are extracted twice while 2 hours for each time. The established optimum extraction process is efficient for the extraction of BXN, and is a stable, economical and convenient method. |
| Keywords: | Chinese herbal Compound BXN anti-diarrhea extraction process orthogonal experiment |
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