Characteristics of Baicalin Synergy with Penicillin or Notopterygium Ethanol Extracts Against Staphylococcus aureus |
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| Authors: | MENG Zhen Chongjin Sop YOU Xuefu XING Dongming WANG Wei DU Lijun |
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| Institution: | 1. Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;1. Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands;2. Department of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands;1. Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences (IOC RCNS HAS), Magyar Tudósok Blvd 2, H-1117 Budapest, Hungary;2. Department of Pharmaceutics, Semmelweis University, Hőgyes St 7, H-1092 Budapest, Hungary;3. Department of Inorganic and Analytical Chemistry, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Szent Gellért Sq 4, H-1111 Budapest, Hungary;1. Department of Physics and Astronomy, University of California, Irvine, CA 92697-4575, USA;2. Instituto de Física, Universidad Nacional Autónoma de México, POB 20-364, Cd.Mx. 01000, Mexico;3. Physik Department T75, Technische Universität München, James-Franck-Straße 1, 85748, Garching, Germany;1. Department of Mechanical Engineering, Amirkabir University of Technology, Tehran, Iran;2. Department of Mechanical Engineering, Shahid Bahonar University of Kerman, Kerman, Iran;3. Department of Engineering Design and Materials, NTNU, Trondheim, Norway;2. Department of Clinical Epidemiology, Biostatistics and Bioinformatics;3. Centre for Reproductive Medicine, Women''s and Children''s Hospital;4. Department of Obstetrics and Gynaecology, Academic Medical Centre at the University of Amsterdam, Amsterdam, Netherlands;5. University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Institute of Metabolic Science, Cambridge, United Kingdom;6. Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany;7. Life Length Inc., Madrid, Spain |
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| Abstract: | Baicalin facilitates the effectiveness of both penicillin and Notopterygium ethanol extracts (NEE) on Staphylococcus aureus. Two Staphylococcus aureus strains, ATCC29213 and 03-21 (a clinical isolate), were tested. When combined with 128 μg · mL−1 of baicalin, the minimum inhibitory concentration (MIC) of penicillin was reduced from 0.25 μg · mL−1 to 0.06 μg · mL−1, while that of NEE was reduced from 32 μg · mL−1 to 8 μg · mL−1 against ATCC29213. Against the 03-21 strain, the MIC of penicillin was reduced from 4 μg · mL−1 to 1 μg · mL−1, while that of NEE was reduced from 32 μg · mL−1 to 4 μg · mL−1. Viable number counting results show that combination of baicalin and penicillin acts on the killing mechanism, while the baicalin and NEE acts on the inhibition. These results show that baicalin acts as a synergistic ally with both penicillin and NEE but has different modes of action. |
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| Keywords: | baicalin synergy minimum inhibitory concentration Staphylococcus aureus |
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