Epigenetic aberrations during oncogenesis |
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Authors: | Maria?Hatziapostolou Email author" target="_blank">Dimitrios?IliopoulosEmail author |
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Institution: | (1) Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA;(2) Department of Pathology, Harvard Medical School, Boston, MA 02115, USA; |
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Abstract: | The aberrant epigenetic landscape of a cancer cell is characterized by global genomic hypomethylation, CpG island promoter
hypermethylation of tumor suppressor genes, and changes in histone modification patterns, as well as altered expression profiles
of chromatin-modifying enzymes. Recent advances in the field of epigenetics have revealed that microRNAs’ expression is also
under epigenetic regulation and that certain microRNAs control elements of the epigenetic machinery. The reversibility of
epigenetic marks catalyzed the development of epigenetic-altering drugs. However, a better understanding of the intertwined
relationship between genetics, epigenetics and microRNAs is necessary in order to resolve how gene expression aberrations
that contribute to tumorigenesis can be therapeutically corrected. |
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Keywords: | |
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