(1) State Key Laboratory of Chemo/biosensing and Chemometrics, Engineering Center for Biomedicine, Institute of Life Science and Biological Technology, Hunan University, Engineering Research Center for Bio-Nanotechnology of Hunan Province, 410082 Changsha, China
Abstract:
The routine method for preparation of silica core-shell nanoparticles (NPs) is to carry out nucleation and shell coating through the hydrolysis of silane in water in oil (W/O) microemulsion to form three-dimensional netted silica shell. We found that electrostatic interaction of the core ma- terials with shell materials would determine whether the stable core-shell silica NPs formed or not. The traditional important factors such as molecular weight of core materials or the thickness of the shell have no obvious relationship with it. And the stability of the core-shell silica NPs can be im- proved after changing the electric charge polarity by regu- lating the experiment condition of relevant materials if some core materials cannot be doped inside to form the stable core-shell silica NPs based on the traditional method, which provided experimental and theoretic foundation for prepara- tion and application of the core-shell silica NPs.