Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes |
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Authors: | Igor Adameyko Francois Lallemend |
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Institution: | 1. Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles v?g 1-A1-plan2, 171 77, Stockholm, Sweden
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Abstract: | Melanocytes and Schwann cells are derived from the multipotent population of neural crest cells. Although both cell types
were thought to be generated through completely distinct pathways and molecular processes, a recent study has revealed that
these different cell types are intimately interconnected far beyond previously postulated limits in that they share a common
post-neural crest progenitor, i.e. the Schwann cell precursor. This finding raises interesting questions about the lineage
relationships of hitherto unrelated cell types such as melanocytes and Schwann cells, and may provide clinical insights into
mechanisms of pigmentation disorders and for cancer involving Schwann cells and melanocytes. |
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Keywords: | |
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