Protein kinase TTK interacts and co-localizes with CENP-E to the kinetochore of human cells |
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Authors: | Jie Zhang Chuanhai Fu Yong Miao Zhen Dou Xuebiao Yao |
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Institution: | (1) Laboratory of Cell Dynamics, University of Science & Technology of China, 230027 Hefei, China |
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Abstract: | Spindle checkpoint is an important biochemical signaling cascade during mitosis which monitors the fidelity of chromosome
segregation, and is mediated by protein kinases Mps1 and Bub1/BubR1. Our recent studies show that kinesin-related motor protein
CENP-E interacts with BubR1 and participates in spindle checkpoint signaling. To elucidate the molecular mechanisms underlying
spindle checkpoint signaling, we carried out proteomic dissection of human cell kinetochore and revealed protein kinase TTK,
human homologue of yeast Mps1. Our studies show that TTK is localized to the kinetochore of human cells, and interacts with
CENP-E, suggesting that TTK may play an important role in chromosome segregation during mitosis. |
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Keywords: | spindle checkpoint TTK protein kinase CENP-E kinetochore |
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