| 卡马西平对吗啡依赖小鼠戒断症状的影响 |
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| 引用本文： | 叶少剑,肖智勇,陈晓青,黄念芳. 卡马西平对吗啡依赖小鼠戒断症状的影响[J]. 江汉大学学报(自然科学版), 2002, 30(1): 5-6 |
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| 作者姓名： | 叶少剑 肖智勇 陈晓青 黄念芳 |
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| 作者单位： | 江汉大学,医学与生命科学学院药理教研室,湖北,武汉,430016 |
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| 基金项目： | 武汉市医药卫生科研基金资助课题 (武卫 [2 0 0 1] 2 3 5号 -4 4) |
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| 摘 要： | 目的 :观察卡马西平对纳洛酮诱发的吗啡依赖小鼠戒断症状的作用。方法 :皮下注射吗啡 7天 ,建立小鼠吗啡依赖模型。纳洛酮催瘾前 30分钟 ,分组灌胃不同药物 ,观察小鼠戒断反应。结果 :卡马西平(15 0 mg· kg- 1 )及可乐定 (0 .2 4 m g· kg- 1 )能明显降低小鼠跳跃次数 ,减轻体重下降趋势 ,与阴性对照组比较差异有显著意义 ;对腹泻症状也有缓解作用。结论 :单用卡马西平能有效控制纳洛酮诱发的小鼠戒断症状 ,效果与可乐定相似
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| 关 键 词： | 卡马西平 吗啡依赖 戒断症状 小鼠 |
| 文章编号： | 1009-1777(2002)01-0005-02 |
| 修稿时间： | 2001-07-05 |
The Effects of Carbamazepine on the Withdrawal Syndrome in Morphine Dependent Mice |
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| YE Shao jian,XIAO Zhi yong,CHEN Xiao qing,et al.. The Effects of Carbamazepine on the Withdrawal Syndrome in Morphine Dependent Mice[J]. Journal of Jianghan University(Natural Sciences), 2002, 30(1): 5-6 |
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| Authors: | YE Shao jian XIAO Zhi yong CHEN Xiao qing et al. |
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| Abstract: | Objective: To observe the effects of carbamazepine on the naloxone evoked withdrawal syndrome in morphine dependent mice. Methods: S.c morphine(Mor) 7 days to establish Mor dependent mice model, i.g treatment drugs 30min before i.p naloxone(Nal) 5 mg·kg -1 . Observe the withdrawal syndrome. Results: Carbamazepine 150 mg·kg -1 and clonidine 0.24 mg·kg -1 significantly reduce the jumping number and inhibit the body weight lose of the mice, and improve the diarrhea syndrome. Conclusion: Carbamazepine can effectively inhibit the naloxone evoked withdrawal syndrome of morphine dependent mice, just like the effects of clonidine. |
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| Keywords: | carbamazepine morphine dependence withdrawal syndrome mouse |
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