| 维生素C环境友好催化合成阿司匹林 |
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| 引用本文： | 熊知行,袁琳.维生素C环境友好催化合成阿司匹林[J].高师理科学刊,2008,28(5). |
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| 作者姓名： | 熊知行 袁琳 |
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| 作者单位： | 1. 宜春学院,化学与生物工程学院,江西,宜春,336000;江西省高等学校应用化学与化学生物学重点实验室,江西,宜春,336000
2. 宜春学院,化学与生物工程学院,江西,宜春,336000 |
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| 基金项目： | 江西省高校重点实验室科技计划项目，江西省教育科学规划项目 |
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| 摘 要： | 讨论了将维生素C作为催化剂用于阿司匹林的合成中,其催化剂用量、反应时间、反应温度对产品收率的影响.当水杨酸用量为4.0 g,醋酸酐用量为8.5 mL,维生素C用量为0.1～0.2 g,温度为60～80oC,反应时间为10～25 min,为最佳反应条件.纯化阿司匹林的收率可以达到80.5%,产品系纯白色结晶.结果表明,维生素C对该反应具有良好的催化作用,最佳产品收率可达到80%以上,是合成阿司匹林的优良催化剂.
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| 关 键 词： | 阿司匹林 维生素C 催化 合成 |
Synthesis of Aspirin with Vitamin C as catalyst |
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| XIONG Zhi-xing,YUAN Lin.Synthesis of Aspirin with Vitamin C as catalyst[J].Journal of Science of Teachers＇College and University,2008,28(5). |
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| Authors: | XIONG Zhi-xing YUAN Lin |
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| Institution: | XIONG Zhi-xing1,2,YUAN Lin1(1.School of Chemistry , Bioengineering,Yichun University,Yichun 336000,China,2.Key Laboratory of Jiangxi University for Applied Chemistry , Chemical Biology,China) |
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| Abstract: | The catalyst of Vitamin C was first used in the synthesis of Aspirin.The effects of dose of catalyst-crude ratio,reaction time and reaction temperature on the yield of Aspirin are discussed.It showed that when the amount of salicylic acid was 4.0 g,acetic anhydride8.5 mL,Vitamin C 0.1~0.2 g,75oC reaction for10~25min,the yield of purified Aspirin was 80.5%.Experimental results show that Vitamin C could be used as a catalyst for acylation of salicylic acid instead of sulphuric acid.The yield could reach 80.5%... |
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| Keywords: | Aspirin Vitamin C catalysis synthesis |
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