Development of new hypoxic cell sensitizers: Amides of nitrobenzoic acid with spermidine and spermine |
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| Authors: | Y Nagao S Takao E Fujita C Murayama T Mori T Asao T Suzue |
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| Institution: | (1) Institute for Chemical Research, Kyoto University, 611 Uji Kyoto-Fu, Japan;(2) Department of Radiology, School of Medicine, Tokai University, Bonseidai, 259-11 Isehara Kanagawa-ken, (Japan);(3) Research Laboratory, Taiho Pharmaceutical Co., Ltd, Kawauchi-cho, 771-01 Tokushima, (Japan) |
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| Abstract: | Summary New type hypoxic cell sensitizers, N1, N10-bis(4-nitrobenzoyl)spermidine (1) and N1,N14-bis(4-nitrobenzoyl)-spermine (2), have been developed. These compounds were shown to be more effective radiosensitizers to hypoxic cells than misonidazole (3). |
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