Direct relationship between urinary prostaglandin E and sodium excretion in essential hypertensive patients |
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| Authors: | N. Papanicolaou N. Lefkos M. Safar M. Paris J. Bariety M. Milliez |
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| Affiliation: | (1) Centre de Recherches sur l'Hypertension Artérielle, INSERM (U-28), Hôpital Broussais, F-75014 Paris, (France);(2) Centre de Recherches sur les Hormones Vasoactives et sur la Physiopathologie Rémale et Vasculaire, Faculté de Médecine de l'Université d'Athènes, Départment de Microbiologie, Athènes, (Grèce) |
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| Abstract: | Summary Urinary prostaglandins (PGEs and PGFs), sodium and potassium were measured in 17 essentially hypertensive patients. Significant positive correlations were found between a) PGEs secreted in 24 h and sodium excreted in 24 h, b) the ratio PGEs/UNaV before and PGEs/UNaV after volume expansion and c) the ratio Na/K and urinary PGEs. It was suggested that renal PGEs, potent natriuretic and diuretic substances, play an important homeostatic role in the extracellular fluid regulation, and consequently in long-term control of the arterial blood pressure. |
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